Spink1 Mutation in Idiopathic Recurrent Acute Pancreatitis-Pilot Study

Genetics in idiopathic pancreatitis and acute recurrent pancreatitis.

Acute recurrent pancreatitis (ARP) occurs in 10-35% of children presenting idiopathic acute pancreatitis (IAP) and can evolve to chronic pancreatitis (CP), especially if genetic mutations are present.

Mutation analysis of PRSS1, SPINK1 and CFTR gene in patients with alcoholic and idiopathic chronic pancreatitis: A single center study.

BACKGROUND/AIMS A relation between some genetic mutations and chronic pancreatitis (CP) has been reported. However, the relation of genetic mutation to alcoholic CP (ACP) and idiopathic CP (ICP) still remains controversial. In this study, we investigated the prevalence of protease serine 1 (PRSS1), serine protease inhibitor, Kazal type 1 (SPINK1) SPINK1 and cystic fibrosis transmembrane conduct...

Genetic mutations in SPINK1, CFTR, CTRC in acute pancreatitis

Background. The explanation of the ultimate causes of acute and chronic pancreatitis is

Genetic mutations in SPINK1, CFTR, CTRC genes in acute pancreatitis

BACKGROUND Explanation of the ultimate causes of acute and chronic pancreatitis is challenging. Hence, it is necessary to seek various etiological factors, including genetic mutations that may be of importance in triggering recurrence and progression of acute to chronic pancreatitis. The aim of this study was to determine the frequency of genetic mutations in patients with acute pancreatitis an...

Recurrent Acute Pancreatitis: A Diagnostic Clue to Primary Hyperparathyroidism